Quantifying Basal Ganglia Thalamic Injury in Neonatal Hypoxic Ischemic Encephalopathy – A Method for Early Assessment of CP Risk

Hypoxic ischemic encephalopathy (HIE) refers to brain injury resulting from reduced blood and oxygen delivery to a baby’s brain near the time of birth. Advanced magnetic resonance imaging (MRI) is a safe, non-invasive tool that can be used to measure tissue health and blood flow in deep brain structures. Using brain MRI measurements in newborns to predict later childhood disability can advance clinical care by providing means to assess the immediate effects of treatments for brain injury. This project aims to evaluate advanced MRI tools that can help prevent or ameliorate disability due to cerebral palsy that is often a consequence of HIE and other neurologic disorders in the newborn.

Principal Investigator: Dr. An Massaro, MD, MPH at George Washington University.